Flying IFR part 91 gives you a lot of freedom to kill yourself. I think as long as you have a clearance you can takeoff .
You would be responsible for your own terrain clearance and ATC would protect the airspace.
The best way to depart would be to circle the airport until you reach the MSA of 10,300ft then go direct to a waypoint or vor.
I would want to have synthetic vision to do that, but that is a personal minimum.
Honestly I think I would head back to the hotel.